Unit Converter
Triglycerides
(Major Circulating Lipid - Critical Marker for Cardiovascular Risk, Metabolic Syndrome & Pancreatitis)
Synonyms
- Triglycerides
- Triacylglycerol (TAG)
- Serum triglyceride
- Neutral fats
- TG level
- Blood fats
Units of Measurement
- mmol/L
- µmol/L
- mg/dL
- mg/100 mL
- mg%
- mg/L
- µg/mL
Unit Conversions
Molecular Weight (average TG molecule) ≈ 885 g/mol
(Used for standard TG conversions.)
mmol/L ↔ mg/dL
1 mmol/L=88.5 mg/dL1\ \text{mmol/L} = 88.5\ \text{mg/dL}1 mmol/L=88.5 mg/dL 1 mg/dL=0.0113 mmol/L1\ \text{mg/dL} = 0.0113\ \text{mmol/L}1 mg/dL=0.0113 mmol/L
µmol/L ↔ mg/L
1 µmol/L=0.885 mg/L1\ \text{µmol/L} = 0.885\ \text{mg/L}1 µmol/L=0.885 mg/L 1 mg/L=1.13 µmol/L1\ \text{mg/L} = 1.13\ \text{µmol/L}1 mg/L=1.13 µmol/L
mg/100 mL = mg% = mg/dL
µg/mL ↔ mg/L
1 µg/mL=1 mg/L1\ \text{µg/mL} = 1\ \text{mg/L}1 µg/mL=1 mg/L
Description
Triglycerides (TGs) are esters of glycerol + 3 fatty acids, representing:
- The main storage form of fat in humans
- A key circulating lipid transported by:
- Chylomicrons (post-meal)
- VLDL (endogenous production by liver)
- Chylomicrons (post-meal)
They serve as a major energy source and a central component of metabolic dysfunction.
Elevated triglycerides are strongly linked with:
- Atherosclerotic cardiovascular disease (ASCVD)
- Insulin resistance
- Pancreatitis
- Fatty liver (MASLD/NAFLD)
Physiological Role
- Energy storage & release (lipolysis → free fatty acids)
- Transport of dietary fat (via chylomicrons)
- Substrate for gluconeogenesis
- Component of metabolic pathways (VLDL → LDL cascade)
Clinical Significance
HIGH TRIGLYCERIDES (Hypertriglyceridemia)
1. Metabolic Syndrome / Insulin Resistance (most common)
- Obesity
- Type 2 diabetes
- PCOS
- Sedentary lifestyle
2. Dietary Causes
- High carbohydrates
- Sugars / fructose
- Excess alcohol
3. Secondary Causes
- Hypothyroidism
- CKD
- Nephrotic syndrome
- Pregnancy
- Liver disease (steatosis)
- Medications (steroids, OCPs, isotretinoin, antipsychotics, beta blockers)
4. Genetic Disorders
- Familial hypertriglyceridemia
- Familial combined hyperlipidemia
- Lipoprotein lipase deficiency
- ApoC-II deficiency
5. Pancreatitis Risk
TG >1000 mg/dL (11.3 mmol/L)⇒high risk\text{TG } > 1000\ \text{mg/dL (11.3 mmol/L)} \Rightarrow \text{high risk}TG >1000 mg/dL (11.3 mmol/L)⇒high risk TG >2000 mg/dL⇒very high risk\text{TG } > 2000\ \text{mg/dL} \Rightarrow \text{very high risk}TG >2000 mg/dL⇒very high risk
LOW TRIGLYCERIDES
Less common. Seen in:
- Malnutrition
- Hyperthyroidism
- Malabsorption
- Chronic illness
- Abetalipoproteinemia (extremely low TG)
Reference Intervals
(NCEP ATP III + ACC/AHA + ESC/EAS)
Normal Fasting TG
- <150 mg/dL
(= <1.7 mmol/L)
Borderline High
- 150–199 mg/dL
(= 1.7–2.2 mmol/L)
High
- 200–499 mg/dL
(= 2.3–5.6 mmol/L)
Very High
- ≥500 mg/dL
(= ≥5.7 mmol/L)
Risk of pancreatitis rises sharply.
Critical Levels
- >1000 mg/dL (11.3 mmol/L) → acute pancreatitis risk
- >2000 mg/dL (22.6 mmol/L) → lipemic serum, very high risk
Diagnostic Uses
1. Cardiovascular Risk Assessment
TG contributes to:
- ASCVD
- Atherogenic dyslipidemia
- Remnant cholesterol elevation
2. Metabolic Syndrome Diagnosis
TG ≥150 mg/dL is one of the criteria.
3. Pancreatitis Risk Stratification
TG >1000 mg/dL is a medical emergency.
4. Monitoring Therapy
- Lifestyle interventions
- Statins
- Fibrates
- Omega-3 fatty acids
- Insulin therapy in severe cases
5. Evaluation in fatty liver (MASLD/NAFLD)
High TG common.
Analytical Notes
- Fasting sample preferred (8–12 hours).
Non-fasting acceptable for ASCVD screening (<200 mg/dL stable). - Hemolysis & lipemia may interfere.
- Enzymatic colorimetric assays used in automated analyzers.
- Avoid alcohol 48 hours before test for accurate interpretation.
Clinical Pearls
- TG rise post-meal due to chylomicron surge - use fasting test for accuracy.
- High TG + low HDL = classic insulin-resistance pattern.
- Very high TG (>1000 mg/dL) requires urgent reduction with insulin, heparin, fluids.
- Statins lower TG modestly; fibrates and omega-3 fatty acids lower it more strongly.
- TG lowering reduces pancreatitis risk; LDL lowering reduces ASCVD risk.
Interesting Fact
Triglycerides are transported through blood as oil droplets inside lipoproteins - the body’s way of moving hydrophobic fat in a water-based environment.
References
- Tietz Clinical Chemistry & Molecular Diagnostics, 8th Edition - Lipids & Lipoproteins
- ACC/AHA 2018 & 2022 Cholesterol Guidelines
- NCEP ATP III Lipid Guidelines
- ESC/EAS 2019 Dyslipidemia Guidelines
- Mayo Clinic Laboratories - Triglycerides
- ARUP Consult - Lipid Disorders
- NIH / MedlinePlus - Triglycerides
